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Novo Nordisk Senior Scientist Bioanalysis in Indianapolis West, Indiana

About the Department Novo Nordisk Research Center Indianapolis, Inc. (NNRCII) is the home of the Transformational Research Unit-Chemical Biology, an elite research team working autonomously yet in union within Novo Nordisk's global research mission to transform the management of cardio-metabolic diseases. Enabled by the Novo Nordisk Research and Development organization, the mission of these global transformational research units is to bring forth projects that will expand and diversify the Novo Nordisk pipeline of life-changing medicines. As a Transformational Research Unit, the team at NNRCII operates independently from the core organization in order to cultivate the discovery of disruptive research concepts and accelerate translational validation. This center was established in 2016 when Novo Nordisk acquired two private biotechnology companies co-founded by Professor DiMarchi that were focused on developing peptide-based drug candidates for treatment of diabetes and obesity. Our research program has maintained a state-of-the-art, fast paced character that represents the best practices commonly observed in academic, biotech and pharma companies. Our scientists are focused on innovative discovery projects pertaining to the treatment of metabolic disorders. We develop and employ cutting-edge biotechnologies to identify, refine, and select suitable drug candidates that possess novel mechanisms of biological action through collaboration with internationally acclaimed academic centers of excellence and integration within aspects of the global Novo Nordisk Research and Development organization. At NNRCII, your skills, dedication and ambition will help us change lives for the better. We will offer you an opportunity to work with extraordinary talent and to continuously develop, while addressing serious chronic medical conditions. Are you ready to make a difference? The Position Demonstrates scientific leadership through technical support to the therapeutic discovery department at Novo Nordisk Research Center Indianapolis, Inc. (NNRCI) in order to facilitate the discovery of peptide and protein-based bio-therapeutics for the treatment of diabetes, obesity, cardiovascular disease and liver disease. This position is responsible to design and conduct experiments using liquid chromatography (LC) and mass spectrometry (MS) techniques for bioanalytical characterization of therapeutic peptides and proteins. This position will play a critical role in moving projects from target discovery and preclinical target validation to lead candidate optimization and clinical candidate selection. This position requires a highly proficient scientific professional in the specific focus area of LCMS-based bioanalytical characterization of peptide and protein-based therapeutics to determine 1) in vivo pharmacokinetic (PK) parameters and metabolite identification, 2) in vitro drug metabolism, 3) drug transport and molecular biotransformation, 4) comprehensive chemical stability, and 5) advanced peptidomics, proteomics and protein bioanalysis to support target discovery. Relationships Reports to the Director of Biology. Internal relationships include working across the project teams that include project managers, medicinal chemists, in vitro biologists and pharmacologists, as well as in close partnership with individual research colleagues at NNRCI and globally at Novo Nordisk research laboratories in Denmark and Beijing. External relationships include relevant parts of the peptide and protein sciences, analytical chemistry, and metabolic disease biology communities. May serve as the representative to external collaborations including contractual research organizations. Essential Functions * Support research objectives focused on drug metabolism and pharmacokinetics (DMPK), drug delivery, and molecular biotransformation specifically by LCMS-based techniques including LCMS analytical method development, sample preparation and extraction, LCMS data acquisiti